Dr. Jack Humphrey is an Assistant Professor in the Department of Neuroscience at the

Icahn School of Medicine at Mount Sinai. His research focuses on using large-scale

human datasets to understand the genetic and molecular basis of neurodegenerative

disease. He grew up in a small town in the Cheddar Valley in the southwest of England.

He received his Ph.D. in Clinical Neuroscience from University College London in 2019

and previously spent time as a visiting researcher at Stanford University before moving

to New York for a postdoctoral fellowship at Mount Sinai, where he joined the faculty in

2021. He also has a Visiting Scientist position at the New York Genome Center.

 

Dr. Humphrey’s lab develops and applies advanced computational and genomic

methods to analyze human datasets and postmortem tissue samples to better

understand the biology of neurodegenerative diseases. His work focuses particularly on

ALS and Frontotemporal Dementia, while also studying other neurodegenerative

conditions including Alzheimer’s Disease and Parkinson’s Disease. By integrating genetics, functional genomics, and large-scale human data, his research aims to uncover the biological pathways driving these diseases and identify new opportunities for therapeutic development.

 

His research has been supported by organizations including the ALS Association,

Target ALS, My Name’5 Doddie Foundation, CurePSP, Hop on a Cure, the Robert

 

Packard Center for ALS Research at Johns Hopkins, and the National Institutes of

Health.